DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.
نویسندگان
چکیده
منابع مشابه
AL072, a novel anti-Legionella antibiotic produced by Streptomyces sp.
AL072 is a potent anti-Legionella antibiotic produced by Streptomyces strain AL91. The compound was isolated from the fermentation broth with 1 volume of isopropyl alcohol, followed by an ethyl acetate extraction and subsequent concentration under reduced pressure. Purification was performed on an octadecyl silica gel column followed by preparative HPLC. AL072 purified as mentioned above showed...
متن کاملBelactosin A, a novel antitumor antibiotic acting on cyclin/CDK mediated cell cycle regulation, produced by Streptomyces sp.
cyclins or CDKs, and loss or decreased level of endogenous CDKinhibitor proteins such as pi6 and p27 in various tumors have been reported2). Flavopiridol, a specific small molecule-CDK inhibitor, showed potent antitumor activity in a series of experimental tumor models and is currently in clinical trial3). Thus, the CDKs are considered as new molecular targets for cancer chemotherapy. Weestabli...
متن کاملMPC1001, a new antitumor antibiotic produced by Cladorrhinum sp.
In the course of our screening for antitumor antibiotics, MPC1001 was isolated from a microorganism, Cladorrhinum sp. KY4922. MPC1001 exhibited antimicrobial activity, and antiproliferative activity against human tumor cell lines. In this paper, we describe the taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities of MPC1001. The cult...
متن کاملPyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain.
A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various ...
متن کاملPrecursors in the biosynthesis of FR-900482, a novel antitumor antibiotic produced by Streptomyces sandaensis.
isolated from the culture broth of Streptomyces sandaensis No. 6897, was found to have unique structure1*^. FR-900482 differs from the mitomycin family of antibiotics due to the lack of a quinoid structure, although FR-900482 resembles the mitomycins with respect to the aziridine function and a carbamoyloxymethyl group. Examination of the structure suggests that the biosynthesis of FR-900482 ma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1989
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.42.333